Yet, more than 20 years later, there still haven’t been any clinical studies on the safety, toxicity, or potential efficacy of O-acetylpsilocin, despite its rising popularity among psychonauts. Nichols tried to put it on the map as a safe and cost-effective alternative to psilocybin, because it’s much easier (and cheaper) to synthesize. Then in 1999, professor and psychedelic scientist David E. As an employee for the pharmaceutical company Sandoz, Hofmann and his colleague, Franz Troxler, were playing around with molecules similar to psilocin, and patented psilacetin along with four other esters (organic compounds that react to water by producing alcohol) of psilocin in 1963.īut 4-AcO was patented and then largely forgotten, until it reappeared in the 1990s rave scene as a new designer drug. In fact, 4-AcO-DMT was first synthesized in the early 1960s by Albert Hofmann, the same chemist who discovered LSD and first synthesized psilocybin. 4-AcO seems to be very closely related to the magic mushroom compounds psilocybin and psilocin, and like psilocybin, is speculated to break down into psilocin in the body during first pass metabolism. Buy Legal 4-AcO-DMT Online? What is 4-AcO-DMT?Ĥ-AcO-DMT-also known as O-acetylpsilocin, 4-acetoxy-DMT, psilacetin, or “synthetic mushrooms”-is a semi-synthetic research chemical in the tryptamine family, which also includes the classic psychedelics like DMT and psilocybin.
